|
KMID : 0384119860060010085
|
|
Korean Journal of Clinical Pathology
1986 Volume.6 No. 1 p.85 ~ p.90
|
|
|
Clinical Significance of the Isolation of Coagulase negative Staphylococci From Blood Culture
|
|
|
|
|
Abstract
|
|
|
Coagulase-negative staphylococci (CNS) once considered a nonpathogenic skin contaminant, is emerging as a cause of severe infections, especially bacteremia in immunocompromised patients.
Patients were diagnov ~cl as bacteremia due to CNS, if they had the following criteria:
(1) fever (temperature 38°C, orally) with two or more blood culture positivity (2) fever with single positive blood culture associated with a localized CNS infection in other important site.
(3) Three times or more isolation from blood culture, even if without fever. From May 1984 through April 1985, there were 114 episodes of CNS bacteremia in 71 patients at Seoul National University Hospital. CNS was the 2nd most common organism isolated, responsible for 12.7% of all bacteremic episodes. 57. 4% of isolated CNS is considered to be of clinical importance. The results are as follows.
l. The most frequent underlying disease was congenital anomaly of heart valve or main blood vessels (28.301o), followed by malignancy (10.4%), disorder of gastrointestinal tract (9.0% ), acquired disorder of heart of vasculature, disease in neonate and infant.
2. Other important site of concurrent culture, in addition to one or more blood culture yielding CNS were I . V. catheter (3 cases), urine (1 case), wound pus(1 case).
3. There were 3 episodes of concurrent polymicrobial septicemia associated with CNS bacteremia (Kl. oxytoca, pseudomonas spp, S. aureus). One patient had
prior episode of bacteremia with a-hernol>tic streptococci before the occurence of CNS bacteremia.
4. Before the onset of CNS bacterenia, 17 patients had instrumentation (I . V. Catheter lii e (7) , Foley catheter (5) , nasogastric tube (3) , chest tube (2)) .
5. in antimicrobial susceptibility test, resistance to penicillin, (37.0/0), tetracyclin(74.2%), erythro ycin(74.2%) was noted, and multiple resistance to 3 or more drugs was 87.9%, however, most of them were sensitive to cephalothin.
6. The overall 12.9% mortality rate was associated with CNS bacteremia.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|
|